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Introduction
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Endometrial Receptivity Analysis (ERA) is a molecular biology test that simulates an implantation cycle to determine if the endometrium is receptive to embryo implantation after five consecutive days of progesterone stimulation. The procedure involves using Next-Generation Sequencing (NGS) to analyze 248 genes related to endometrial receptivity in endometrial tissue, assessing the uterus's readiness to accept an embryo.
Who Should Consider ERA?
✅ Older women
✅ Recurrent miscarriage
✅ Multiple failed implantations of chromosomally normal embryos
ERA Risks:
If the initial ERA results indicate that the "implantation window is too far from or too close to the biopsy date," the report will suggest a recommended time for a second test.
In approximately <1% of cases, the result may be "no signal," and in <5% of cases, there may be insufficient samples or poor-quality endometrial tissue, requiring a new sample for testing.