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Introduction
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PGS, now known as Preimplantation Genetic Testing for Aneuploidies (PGT-A), is a procedure that checks for the presence of an abnormal amount of chromosomes in each of your embryos before the embryo transfer in an IVF treatment.
Typically, 5 to 8 cells are sampled for testing, providing a more accurate representation of the embryo's overall chromosomal status compared to day 3 biopsies. This technology helps avoid the implantation of abnormal embryos, increases pregnancy rates, reduces miscarriage rates, and addresses issues such as recurrent miscarriage and a family history of chromosomal abnormalities. It can also assist couples who have experienced multiple failed traditional IVF cycles by shortening the time to a successful pregnancy.
*Please discuss with your physician if you want to undergo PGT-A testing*
Who should receive PGS screening?
- Women over the age of 35
- Those who have more than 2 miscarriages
- Those who experienced repeated IVF failures
- Those with a family history of chromosomal abnormalities or chromosomal translocation
- Male infertility syndrome
PGS can detect diseases like:
- Down Syndrome, Turner’s Disease, Edward’s Disease, Patau Disease
- Large chromosome deletion (>10Mb): Prader-Willi Syndrome, Cri Du Chat Syndrome, DiGeorge Syndrome, Angelman Syndrome
Can PGS fail to screen out abnormal conditions?
- The embryo could be mosaic, and depending on the severity of the case it may be unable to develop normally after transfer
- The sample size is small (<10Mb)
- Cannot distinguish balanced and structurally normal embryos from translocation carriers
*Please receive a Chorionic Villus Sampling (CVS) or Amniocentesis after a successful pregnancy through a PGT-A test.*
Q&A
Is it guaranteed that I’m able to have an easy pregnancy and healthy child after receiving a PGS test?
Although this advanced scientific approach does improve the chances, there are still limitations to PGS or PGD. Some abnormalities may go undetected. Please still regularly receive pregnancy checkups.
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